CELE_T21E3.1, T21E3.1

egg-4 encodes a pseudotyrosine phosphatase; egg-4, along with egg-5 which also encodes a pseudotyrosine phosphatase, are required for the egg-to-oocyte transition and embryonic development; EGG-4 and EGG-5 function to negatively regulate the activity of the MBK-2 DYRK family kinase by sequestering MBK-2 at the oocyte cortex and, in the case of EGG-4, by inhibiting its enzymatic activity; EGG-4 physically interacts with MBK-2 and in in vitro assays, appears to function as a mixed-type inhibitor of MBK-2 kinase activity; EGG-4 localizes to the oocyte cortex and nuclei.

37453

6239