CELE_M04F3.5

M04F3.5 encodes an I-BAR domain-containing protein; upon incubation with multilamellar vesicles, the I-BAR domain of M04F5.3 binds the inner membrane leaflet and inserts an amphipathic alpha helix into the bilayer to effect clustering of PI(4,5)P2 and formation of outwardly facing tubules of characteristic diameter; when expressed in U2OS cells, the M04F5.3 I-BAR domain localizes to filopodia and forms relatively stable structures, when compared to its mammalian counterpart, within the plasma membrane protrusions.

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