CELE_F57C9.5, F57C9.5

htp-3 encodes a HORMA domain-containing protein that is one of three C. elegans HIM-3 paralogs; during meiosis, htp-3 activity is required for homologous chromosome alignment and synapsis, and for meiotic double strand break formation; immunoprecipitation experiments indicate that HTP-3 interacts in vivo with complexes containing MRE-11 and RAD-50, and HIM-3; HTP-3 is expressed in the germline where it localizes to chromatin in premeiotic nuclei and, with HIM-3, to the axes, or cores, of meiotic chromosomes; HTP-3 localization to premeiotic chromatin and meiotic chromosomes is dependent upon scc-3 activity, while in turn HIM-3 localization to meiotic chromosomal axes, and SYP-1 localization to the synaptonemal complex, is dependent upon HTP-3 activity.

37561

6239