Caenorhabditis elegans
SPD-5
CELE_F56A3.4, F56A3.4
spd-5 encodes a coiled-coil domain protein; spd-5 activity is required for centrosome maturation, symmetry breaking, pronuclear migration, mitotic spindle assembly, and cell division; in regulating centrosome maturation, spd-5 interacts genetically with spd-2, which also encodes a coiled-coil protein; SPD-5 physically interacts with CED-9, a C. elegans BCL2 ortholog and spd-5(RNAi) results in increased germline apoptosis, suggesting an additional role for SPD-5 in regulation of apoptosis; SPD-5 localizes to the pericentriolar material.
GO Process (8)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
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- Interactors 20
- Interactions 34
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