CELE_F56A3.4, F56A3.4

spd-5 encodes a coiled-coil domain protein; spd-5 activity is required for centrosome maturation, symmetry breaking, pronuclear migration, mitotic spindle assembly, and cell division; in regulating centrosome maturation, spd-5 interacts genetically with spd-2, which also encodes a coiled-coil protein; SPD-5 physically interacts with CED-9, a C. elegans BCL2 ortholog and spd-5(RNAi) results in increased germline apoptosis, suggesting an additional role for SPD-5 in regulation of apoptosis; SPD-5 localizes to the pericentriolar material.

37615

6239