Caenorhabditis elegans
LRP-1
CELE_F29D11.1, egf-4, F29D11.1
lrp-1 encodes a low-density lipoprotein (LDL) receptor-like protein most closely related to the vertebrate gp330/megalin/LRP-2 proteins; during development, lrp-1 activity is required in the hyp7 syncytium for completion of molting and for growth beyond the third larval stage; LRP-1 is expressed on the apical surface of the hyp6 and hyp7 syncytia in hermaphrodites and males from hatching through adulthood; as sterol starvation mimics the lrp-1 mutant phenotype, LRP-1 is likely to function as a receptor for sterols normally endocytosed by the hyp7 syncytium.
GO Process (12)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- cell migration [IMP]
- ecdysis, collagen and cuticulin-based cuticle [IMP]
- growth [IMP]
- locomotion [IMP]
- molting cycle, collagen and cuticulin-based cuticle [IMP]
- nematode larval development [IMP]
- positive regulation of locomotion [IMP]
- positive regulation of multicellular organism growth [IMP]
- regulation of cell migration [IGI]
- secretion by cell [IMP]
- sterol transport [IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
37962
6239
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- Interactors 13
- Interactions 14
- Network