Caenorhabditis elegans
GLD-1
CELE_T23G11.3, T23G11.3
gld-1 encodes a protein containing a K homology (KH) RNA binding domain; GLD-1 is required for regulation of the mitosis/meiosis decision during germline development (promotion of meiotic entry) in parallel with gld-2, gld-3, and nos-3 and also affects spermatogenesis; GLD-1 physically interacts with the 3'- and 5'UTR of its putative mRNA targets in vitro to negatively regulate their translation; GLD-1 also physically interacts with FOG-2, an F-box protein that promotes spermatogenesis; GLD-1 is expressed in the germ cell cytoplasm at high levels during meiotic prophase; GLD-1 phosphorylation and levels in the distal, mitotic germline are negatively regulated by CYE-1/cyclin E, CDK-2, and the RNA-binding protein FBF-1.
GO Process (11)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- determination of adult lifespan [IMP]
- embryo development ending in birth or egg hatching [IMP]
- gamete generation [IMP]
- germline cell cycle switching, mitotic to meiotic cell cycle [IMP]
- negative regulation of translation [IMP]
- negative regulation of vulval development [IMP]
- oogenesis [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of cell proliferation [IMP]
- regulation of meiosis [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
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- Interactors 86
- Interactions 102
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