Caenorhabditis elegans

DRH-3

CELE_D2005.5, ekl-3, D2005.5
drh-3 encodes a DEAH/D-box helicase; drh-3 is required for germline RNAi and for production of several types of endogenous small RNA molecules; in addition, drh-3 plays an essential role in germ cell proliferation, gamete formation, and chromosome segregation; drh-3 is also involved in resistance to X-ray irradiation and genetic studies suggest that drh-3 may also control expression of small RNAs that regulate cell fate specification via Ras-ERK signaling; DRH-3 interacts with the DCR-1 endoribonuclease essential for several distinct small-RNA-mediated silencing pathways and with the RRF-1 RNA-directed RNA polymerase.
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  • Interactors 18
  • Interactions 26
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