CELE_F43G9.5, F43G9.5

F43G9.5 encodes a NUDIX hydrolase that that inhibits DHC-1 in vivo, and is a (perhaps evolutionarily conserved) target of transcriptional activation by DAF-16; F43G9.5(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that F43G9.5 negatively regulates dynein; while loss of F43G9.5 function has no obvious effect on lifespan, dauer formation, or fat storage, F43G9.5 is required for embryonic development, fertility, and general health in mass RNAi assays.

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