Caenorhabditis elegans
LMN-1
CELE_DY3.2, Lam1, DY3.2
lmn-1 encodes the sole C. elegans nuclear lamin; lmn-1 is an essential gene that is required for a number of nuclear processes, including chromatin organization, cell cycle progression, chromosome segregation, and nuclear pore complex spacing; LMN-1 is also required for nuclear envelope localization of EMR-1/Emerin during early development; LMN-1 localizes to the nuclear periphery of all cell types except sperm, and in embryonic and some adult cells is visible in the nuclear interior; LMN-1 binds mitotic chromosomes and histone H2A in a manner that requires its predicted nuclear localization signal, KRRR.
GO Process (17)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- cell cycle arrest [IMP]
- determination of adult lifespan [IMP]
- embryo development ending in birth or egg hatching [IMP]
- germ cell development [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- mitotic nuclear division [IMP]
- nematode larval development [IMP]
- nuclear pore distribution [IMP]
- nucleus organization [IMP]
- positive regulation of cell proliferation [IMP]
- protein localization [IMP]
- regulation of chromosome segregation [IMP]
- regulation of mitotic cell cycle [IMP]
- reproduction [IMP]
- striated muscle myosin thick filament assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
38120
6239
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- Interactors 67
- Interactions 79
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