Caenorhabditis elegans
SPD-2
CELE_F32H2.3, F32H2.3
spd-2 encodes a protein with three predicted coiled-coil domains; SPD-2 activity is essential for centrosome maturation and duplication, and hence for proper mitotic spindle assembly; in regulating the early steps of centrosome maturation, SPD-2 acts together with the coiled-coil protein SPD-5, the Aurora-A kinase AIR-1, and the cytoplasmic dynein DHC-1; in regulating centrosome duplication, SPD-2 likely acts together with the ZYG-1 kinase; in both processes, SPD-2 may function to recruit centrosomal components such as ZYG-9 and microtubule-nucleating gamma-tubulin complexes to the developing centrosome; within centrosomes, SPD-2 localizes to both centrioles and the pericentriolar material; efficient centrosomal localization depends upon AIR-1 and DHC-1, while localization specifically to the pericentriolar material depends upon SPD-5.
GO Process (11)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- centriole replication [IMP]
- centrosome cycle [IMP]
- embryo development ending in birth or egg hatching [IMP]
- engulfment of apoptotic cell [IMP]
- microtubule cytoskeleton organization [IMP]
- microtubule nucleation [IMP]
- mitotic spindle organization [IMP]
- nematode larval development [IMP]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
- vulval development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
38145
6239
Switch View:
- Interactors 16
- Interactions 23
- Network