Caenorhabditis elegans
APH-1
CELE_VF36H2L.1, pen-1, VF36H2L.1
aph-1 encodes an unfamiliar protein predicted to have seven transmembrane domains; APH-1 is a component of the GLP-1/LIN-12 (Notch) pathway, is required maternally for embryonic viability, and also affects morphogenesis, egg laying, germ line proliferation, and translocation of APH-2 to the cell surface; with PEN-2, APH-1 is required for Notch pathway signaling, gamma-secretase cleavage of beta-amyloid precursor protein, and presenilin protein accumulation.
GO Process (9)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
- Notch signaling pathway [IMP]
- cell fate commitment [IGI]
- cell fate commitment involved in pattern specification [IMP]
- embryo development ending in birth or egg hatching [IMP]
- embryonic morphogenesis [IMP]
- locomotion [IMP]
- oocyte development [IMP]
- pharynx development [IMP]
- protein localization to cell surface [IMP]
Download Curated Data for this Protein
38178
6239
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- Interactors 4
- Interactions 4
- Network