CELE_F26E4.1, F26E4.1

sur-6 encodes a regulatory (B) subunit of serine/threonine protein phosphatase 2A (PP2A-B); sur-6 was initially identified in screens for mutations that suppress the Multivulva phenotype produced by an activated let-60/Ras mutation and enhance the vulvaless and larval lethality phenotype of a hypomorphic lin-45/Raf mutation; in addition, RNAi experiments demonstrate that sur-6 activity is also essential for embryonic development; genetic studies indicate that during vulval development SUR-6 likely acts with the KSR-1 kinase in a parallel pathway that positively regulates RTK-Ras-MAP kinase signaling.

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