CELE_F26E4.9, lpd-4, F26E4.9

cco-1 encodes the ortholog of the nuclear-encoded cytochrome c oxidase-1 subunit Vb/COX4, a component of the electron transport chain in mitochondria; knock-down of cco-1 via RNA interference in specific tissues like body wall muscle decreases life span, whereas knock-down in the nervous system and intestine increases life-span; the effects of cco-1 on life span indicate that the electron transport chain functions in a tissue-specific manner to affect the aging process, and studies show that this effect is dependent on the mitochondrial unfolded protein response.

38255

6239