CELE_T23D8.1, T23D8.1

mom-5 encodes one of four C. elegans members of the Frizzled (Fz) family of seven transmembrane receptors; during development, MOM-5 activity is required for asymmetric cell division in the early embryo and during neuronal development, and for attachment of the pharynx to the buccal cavity; MOM-5 is also required for distal tip cell migration in the gonad and for the engulfment of apoptotic cells, indicating that the Wnt pathway signals to CED-10/Rac to regulate cytoskeletal rearrangement during different cellular processes; MOM-5::GFP is enriched at the posterior pole of cells prior to division and during later stages of embryogenesis, is found at the leading edges of epidermal cells during ventral enclosure; in neuroblasts, MOM-5 is required for proper subcellular distribution of DSH-2 to the cortex.

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