CELE_ZK1025.7, ZK1025.7

bah-1 encodes a protein with a DUF23 domain, a domain found in insects, plants, bacteria and two vertebrates, the frog and the fish, Tetraodon, but absent from mammalian genomes; bah-1 normally functions to contribute to the integrity of the nematode cuticle; bah-1 is also required for the surface characteristics of the elegans cuticle that are required for the binding of bacterial biofilms; bah-1 expression is down-regulated in mutants of the TGF-beta pathway, like daf-7, daf-8 or daf-14, as such, these mutants do not form biofilms, suggesting that the TGF-beta pathway regulates bah-1 and possibly other genes required for biofilm binding; bah-1 is expressed in the seam cells which are part of the cuticle-synthesizing hypodermis.

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