Caenorhabditis elegans


CELE_C37A5.9, C37A5.9
pry-1 encodes a protein containing RGS and DIX domains that is distantly related to members of the Axin family of proteins that function as part of a complex that targets beta-catenin for destruction in the absence of Wnt signaling; during C. elegans development, PRY-1 functions as a negative regulator of Wnt signaling pathways that specify cell fates during asymmetric cell division; in addition, pry-1 has been shown to have a role in axon guidance; PRY-1 physically interacts with BAR-1, SGG-1, APR-1, and AXL-1; PRY-1 reporter fusion proteins are expressed in hypodermal and neuronal lineages where they typically localize asymmetrically to the anterior cortex.

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
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