CELE_F49B2.5, kin-22, F49B2.5

src-2 encodes a non-receptor protein tyrosine kinase that, along with src-1, is one of two C. elegans Src family kinase members; although src-2(RNAi) alone results in no overt phenotype, src-2(RNAi) performed in the background of retinoblastoma pathway mutants results in embryonic and larval lethality, as well as sterility; a src-2::GFP reporter fusion is expressed in pharyngeal muscles, the vulva, and some cells around anus; overexpression of SRC-2 in yeast cell results in an overall increase in protein tyrosine phosphorylation levels, which is suppressed by co-expression with CSK-1, a predicted negative regulator of SRC-2 activity.

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