CELE_Y51H7C.11, rpa-6, Y51H7C.11

nol-6 encodes a nucleolar RNA-associated protein (NRAP); in addition to its predicted role in ribosome biogenesis and thus, nucleolar integrity, genetic analysis indicates that nol-6, along with other nucleolar proteins, plays a role in regulation of innate immunity: loss of nol-6 activity via RNAi results in increased resistance to infection by bacterial pathogens in a manner dependent upon cep-1/p53 and sym-1, which encodes a leucine-rich repeat protein, and whose transcription is positively regulated by CEP-1; enhanced resistance of nol-6 mutant animals to P. aeruginosa is also dependent upon DAF-16 and PMK-1.

38895

6239