CELE_T22D2.1, T22D2.1

vab-19 encodes an ankyrin repeat-containing protein that is a member of a conserved family of proteins that includes human Kank, a predicted tumor suppressor; during embryonic morphogenesis, vab-19 activity is essential for epidermal elongation and proper attachment of muscle to the epidermis, specifically the localization of attachment structures to muscle-adjacent regions of epidermal cells and normal epidermal actin organization; a VAB-19::GFP fusion protein is expressed in dorsal and ventral epidermal cells where it organizes into circumferential bands and colocalizes with components of epidermal attachment structures; VAB-19::GFP is also detected in mechanosensory neuronal processes; recruitment of VAB-19 to epidermal attachment structures requires activity of VAB-10/Spectraplakin, while VAB-19 and LET-805/Myotactin are mutually required for localization into circumferential stripes.

38965

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