Caenorhabditis elegans
FRH-1
CELE_F59G1.7, F59G1.7
frh-1 encodes the C. elegans frataxin ortholog; by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced motility, decreased pharyngeal pumping and defecation, reduced egg-laying and fertility, hypersensitivity to oxidative stress, and altered adult lifespan; an frh-1::gfp promoter fusion is expressed in neurons, the pharynx, gut, spermatheca and body wall muscle; in the pharynx, FRH-1 localizes to the mitochondria.
GO Process (14)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
- determination of adult lifespan [IMP]
- embryo development [IMP]
- embryo development ending in birth or egg hatching [IMP]
- feeding behavior [IMP]
- growth [IMP]
- iron-sulfur cluster assembly [ISS]
- locomotion [IMP]
- nematode larval development [IMP]
- oviposition [IMP]
- positive regulation of multicellular organism growth [IMP]
- reproduction [IMP]
- response to hydrogen peroxide [IMP]
- response to stress [IMP]
- response to superoxide [IMP]
Gene Ontology Cellular Component
- mitochondrion [IDA, ISS]
Download Curated Data for this Protein
39343
6239
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- Interactors 3
- Interactions 3
- Network