CELE_F28B12.3, tag-223, F28B12.3

vrk-1 encodes the ortholog of the vaccinia-related protein kinases in metazoans; vrk-1 is required for normal mitosis, proper nuclear envelope formation and regulates the association of the LEM domain protein BAF-1/Barrier-to-autointegration factor (and possibly other LEM domain proteins) with chromatin via BAF-1 phosphorylation; vrk-1 is required for germ cell proliferation and acts in part through regulation of CEP-1/p53; vrk-1 is also required for development of the egg-laying system including several processes like formation of the vulva, the specification and proliferation of uterine cells and sex myoblasts, and anchor cell invasion of the basement membrane between the vulva and somatic gonad; VRK-1 is expressed in neurons, hypodermal cells and vulval cells, and localizes to the nuclear envelope and chromatin in a cell-cylce dependent manner.

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