Caenorhabditis elegans
FBF-1
CELE_H12I13.4, H12I13.4
fbf-1 encodes an RNA-binding protein that is one of 12 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-1 is nearly identical to FBF-2 with which it is largely redundant in regulating two aspects of germline development: 1) maintenance of stem cell proliferation, and 2) the hermaphroditic switch between spermatogenesis and oogenesis; FBF-1 also plays a role in regulating adaptation in the AWC chemosensory neuron by binding and enhancing translation of the egl-4 mRNA; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.
GO Process (12)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- feminization of hermaphroditic germ-line [IMP]
- germ cell development [IMP]
- germline cell cycle switching, mitotic to meiotic cell cycle [IGI, IMP]
- locomotion [IMP]
- masculinization of hermaphroditic germ-line [IMP]
- negative regulation of translation [IGI]
- negative regulation of vulval development [IMP]
- posttranscriptional regulation of gene expression [IGI]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
- spermatogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
39357
6239
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- Interactors 11
- Interactions 25
- Network