Caenorhabditis elegans
PHB-2
CELE_T24H7.1, T24H7.1
phb-2 encodes the C. elegans ortholog of prohibitin PHB2; loss of phb-2 activity via RNAi indicates that phb-2 function is required for mitochondrial organization and morphology and for embryonic, germline, and somatic gonad development; PHB-2, along with prohibitin subunit PHB-1, forms a macromolecular complex that localizes to mitochondrial membranes; PHB-1 and PHB-2 are dependent upon one another for stability: loss of either phb-1 or phb-2 activity via RNAi results in depletion of both protein products.
GO Process (14)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- defecation [IMP]
- determination of adult lifespan [IMP]
- embryo development ending in birth or egg hatching [IMP]
- endoplasmic reticulum unfolded protein response [IMP]
- gonad development [IMP]
- mitochondrion morphogenesis [IMP]
- oogenesis [IMP]
- positive regulation of multicellular organism growth [IMP]
- regulation of oxidative phosphorylation [IMP]
- regulation of pharyngeal pumping [IMP]
- reproduction [IMP]
- response to oxidative stress [IMP]
- spermatogenesis [IMP]
Gene Ontology Cellular Component
Download Curated Data for this Protein
39374
6239
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- Interactors 21
- Interactions 21
- Network