Caenorhabditis elegans
LGG-1
CELE_C32D5.9, atg-8.1, 2G636, C32D5.9
lgg-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Atg8p and mammalian MAP-LC3; by homology, LGG-1 is predicted to be required for the degradation of cellular components by autophagy; loss of lgg-1 function via RNAi indicates that, like several other C. elegans genes involved in autophagy, lgg-1 is essential for normal dauer morphogenesis and life-span extension; a GFP::LGG-1 reporter fusion protein is expression in several different stages of development in multiple tissues, including the nervous system, pharynx, intestine, hypodermis, somatic gonad and vulva; under normal growth conditions, GFP::LGG-1 shows a diffuse cytoplasmic localization, but during dauer formation and in long-lived animals, GFP::LGG-1 shows a marked increase in punctate staining in hypodermal seam cells that likely reflects an increase in the number of preautophagosomal and autophagosomal structures.
GO Process (9)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- autophagy [IGI, IMP]
- dauer larval development [IGI]
- defense response to Gram-positive bacterium [IEP]
- determination of adult lifespan [IGI, IMP]
- embryo development ending in birth or egg hatching [IMP]
- growth [IMP]
- necrotic cell death [IMP]
- positive regulation of necrotic cell death [IGI]
- programmed cell death [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
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- Interactors 78
- Interactions 84
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