CELE_C32D5.9, atg-8.1, 2G636, C32D5.9

lgg-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Atg8p and mammalian MAP-LC3; by homology, LGG-1 is predicted to be required for the degradation of cellular components by autophagy; loss of lgg-1 function via RNAi indicates that, like several other C. elegans genes involved in autophagy, lgg-1 is essential for normal dauer morphogenesis and life-span extension; a GFP::LGG-1 reporter fusion protein is expression in several different stages of development in multiple tissues, including the nervous system, pharynx, intestine, hypodermis, somatic gonad and vulva; under normal growth conditions, GFP::LGG-1 shows a diffuse cytoplasmic localization, but during dauer formation and in long-lived animals, GFP::LGG-1 shows a marked increase in punctate staining in hypodermal seam cells that likely reflects an increase in the number of preautophagosomal and autophagosomal structures.

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