CELE_T01H3.1, T01H3.1

vha-4 encodes an ortholog of subunit c'' of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-4 is a predicted V-ATPase transmembrane rotor component; VHA-4 is paralogous to the c subunits VHA-1/-2/-3, and is predicted to help carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-4 is required for ovulation and embryogenesis, since vha-4(RNAi) animals are sterile with polyploid, unmatured oocytes and dead progeny; VHA-4 is required for alae formation, like the V0 subunits VHA-1 and VHA-5, but not like the V1 subunits VHA-8 or VHA-13; vha-4 is expressed in the excretory cell, the rectum, and a pair of cells near the anus.

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