Caenorhabditis elegans
ZYG-11
CELE_C08B11.1, C08B11.1
zyg-11 encodes a protein containing four diverged leucine-rich repeats and an armadillo-like helical domain and is conserved in metazoa, but not found in Drosophila; during development, ZYG-11 functions as the substrate-recognition subunit for a CUL-2-based ubiquitin-ligase complex that is required for a number of biological processes including progression through meiotic anaphase II, mitotic chromosome condensation, and establishment of anterior/posterior polarity in the early embryo; ZYG-11 interacts with CUL-2 in vivo and with ELC-1/elongin C in vitro.
GO Process (8)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
- anterior/posterior axis specification, embryo [IMP]
- embryo development [IMP]
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- meiotic nuclear division [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IMP]
- positive regulation of metaphase/anaphase transition of meiotic cell cycle [IMP]
- sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
39616
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- Interactors 9
- Interactions 13
- Network