CELE_F10B5.4, F10B5.4

tub-1 encodes a TUBBY homolog that affects fat storage across species including C. elegans; tub-1 functions with kat-1, a 3-ketoacyl-coA thiolase, to affect lipid accumulation; tub-1 is also required for normal life span as tub-1 mutants show extended life span which is dependent on daf-16/FOXO3a; tub-1 interacts with a novel RabGTPase-activating protein RBG-3 and upregulates the activity of a small GTPase, RAB-7, suggesting the involvement of an endocytic pathway in regulating fat storage; tub-1 is expressed in ciliated neurons where its activity is required for proper localization of G protein-coupled receptors to nonmotile primary cilia; tub-1 localizes predominantly to the cytoplasm, but undergoes transport supporting its involvement in neuronal trafficking and chemosensation.

39641

6239