CELE_K01C8.9, K01C8.9

nst-1 encodes a homolog of human GNL3 (OMIM:608011, nucleostemin) and GNL3L, and of S. cerevisiae NUG1; NST-1 may suppress tumorous growth in the germ line by ensuring robust larval germline proliferation; like PRO-1, -2, and -3, NST-1 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germ line; nucleostemin is a nucleolar protein found in stem cells that is required in quantitatively correct amounts (neither too little nor too much) for continued cell division and survival by stem cells or transformed cells; NST-1 is required in mass RNAi assays for normally rapid growth, larval viability, and normal body morphology and pigmentation.

39658

6239