TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.
Transforming growth factor-beta (TGF-beta) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-beta superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 ... (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-beta, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-beta signal transduction.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, Cell Line, Cloning, Molecular, Enzyme Activation, Genes, Reporter, Humans, Intracellular Signaling Peptides and Proteins, MAP Kinase Kinase Kinases, Mice, Molecular Sequence Data, Plasminogen Activator Inhibitor 1, Promoter Regions, Genetic, Protein-Serine-Threonine Kinases, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Signal Transduction, Transfection, Transformation, Genetic, Transforming Growth Factor beta
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, Cell Line, Cloning, Molecular, Enzyme Activation, Genes, Reporter, Humans, Intracellular Signaling Peptides and Proteins, MAP Kinase Kinase Kinases, Mice, Molecular Sequence Data, Plasminogen Activator Inhibitor 1, Promoter Regions, Genetic, Protein-Serine-Threonine Kinases, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Signal Transduction, Transfection, Transformation, Genetic, Transforming Growth Factor beta
Science
Date: May. 24, 1996
PubMed ID: 8638164
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