Caenorhabditis elegans

ATF-2

CELE_K08F8.2, K08F8.2

atf-2 encodes a cAMP-dependent transcription factor paralogous to CES-2, a bZip-like transcription factor that plays a key role in regulation of apoptosis; atf-2 activity is required for excretory duct cell development and essential for embryonic development; in regulating excretory duct cell development, ATF-2 controls expression of lin-48; in vitro, ATF-2 binds the regulatory regions of LIN-48 and the autophagy genes BEC-1, and LGG-1; loss of atf-2 activity results in increased LGG-1 and BEC-1 expression, suggesting that ATF-2 negatively regulates lgg-1 and bec-1 expression in vivo; ATF-2 and CES-2 can physically interact in vivo; atf-2 is broadly expressed in embryos, and is also seen in larvae and adults.

GO Process (1)

GO Function (2)

GO Component (0)

Gene Ontology Biological Process

negative regulation of transcription from RNA polymerase II promoter [IMP]

Gene Ontology Molecular Function

RNA polymerase II regulatory region DNA binding [IDA]
protein binding [IPI]

WormBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

39726

6239

Interactors 27
Interactions 35
Network

Result Summary

ATF-2

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II regulatory region DNA binding [IDA]protein binding [IPI]

RNA polymerase II regulatory region DNA binding [IDA]
protein binding [IPI]