CELE_F52H3.1, F52H3.1

let-268 encodes a procollagen lysyl hydroxylase that processes type IV collagen, a collagen secreted and incorporated into the basement membrane during embryogenesis (and encoded partly by emb-9); LET-268 activity is essential for type IV collagen processing and secretion and for the stability, but not the formation of, the basement membrane that provides mechanical support to body wall muscle once contraction begins; LET-268 also appears to be required for pharyngeal muscle contraction.

39884

6239