Caenorhabditis elegans

LOV-1

CELE_ZK945.9, pkd-1, ZK945.9
lov-1 encodes a transmembrane protein orthologous to human PKD1; lov-1 is required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location and acts with PKD-2, a TRPP cation channel; LOV-1 is expressed in three types of male-specific neurons and localizes to the cell bodies and cilia; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB hook sensillum neuron; in vitro, LOV-1 interacts, via its conserved PLAT domain, with the N-terminus of ATP-2, the beta subunit of ATP synthase that also localizes to cilia, suggesting that ATP synthase may play a role in C. elegans polycystin signaling.
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