CELE_C06A1.1, phi-31, C06A1.1

cdc-48.1 encodes a type II AAA ATPase, homologous to yeast Cdc48 and mammalian p97/VCP, that functions as a ubiquitin-selective chaperone; cdc-48.1 acts redundantly with cdc-48.2 and in conjunction with ufd-1 and npl-4 in endoplasmic reticulum-associated protein degradation (ERAD); in addition, CDC-48.1, UFD-2 and chn-1 function together to regulate myosin assembly and muscle formation via the UNC-45 myosin chaperone, and CDC-48.1 and ATX-3 function together in determination of adult lifespan via interaction with the DAF-2-mediated insulin signaling pathway; cdc-48.1 and cdc-48.2 also interact to provide an essential function during embryonic development; CDC-48.1 exhibits ATPase activity in vitro, and in yeast two-hybrid assays, CDC-48.1 interacts with itself, CDC-48.2, ATX-3, UFD-1, and UBXN-1, consistent with studies in yeast and mammals that show CDC48 homologs form homohexameric complexes that interact with adaptor proteins homologous to UFD-1 and UBXN-1.

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