Caenorhabditis elegans
NUO-1
CELE_C09H10.3, C09H10.3
nuo-1 encodes a encodes a 51 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, and progression through development; nuo-1 is orthologous to human NDUFV1 (OMIM:161015, mutated in Leigh syndrome); nuo-1(ua1) induces a developmental arrest at the third larval (L3) stage that blocks reproduction, and thus is lethal to a population homozygous for nuo-1(ua1); yet arrested L3 nuo-1(ua1) animals have an individual lifespan significantly longer than normal.
GO Process (16)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
- cellular respiration [IMP]
- dauer exit [IMP]
- defecation [IMP]
- determination of adult lifespan [IMP]
- embryo development ending in birth or egg hatching [IMP]
- embryonic morphogenesis [IMP]
- gonad development [IMP]
- inductive cell migration [IMP]
- lipid storage [IMP]
- mitochondrial electron transport, NADH to ubiquinone [IMP]
- mitochondrial respiratory chain complex assembly [IMP]
- nematode larval development [IMP]
- pharyngeal pumping [IMP]
- positive regulation of multicellular organism growth [IMP]
- reproduction [IMP]
- response to drug [IMP]
Gene Ontology Cellular Component
Download Curated Data for this Protein
40006
6239
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- Interactors 36
- Interactions 36
- Network