CELE_VW02B12L.1, VW02B12L.1

vha-6 encodes an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-6 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); VHA-6 is expressed in germline (P2 through Z3 cells until the comma stage), on the apical surface of postembryonic intestinal cells, and at the junction between pharynx and intestine; VHA-6 is required for growth and survival past the L1 larval stage; vha-6(RNAi) animals arrest as L1 larvae and remain alive (but do not grow) for one week; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; VHA-6 is predicted to capture protons from V-ATPase transmembrane rotor components and export the protons across the membrane.

40050

6239