CELE_ZK20.3, ZK20.3

rad-23 encodes a protein containing ubiquitin-like (UBL) and ubiquitin-associated (UBA) domains that is a member of the Radiation Sensitivity 23 (RAD23) family of proteasomal ubiquitin receptors; in C. elegans, rad-23 activity is required for normal axon branching; rad-23 displays genetic interactions with png-1, which encodes a peptide-N-glycanase, also required for proper axon branching during vulval development; in addition, large-scale RNAi screens indicate that hermaphrodites treated with rad-23(RNAi) become sick and sterile, suggesting a more general role for rad-23; large-scale yeast two-hybrid experiments report that RAD-23 interacts with the product of ZK1240.2, which encodes a predicted E3 ubiquitin ligase; like its orthologs in yeast and mammals, C. elegans rad-23 functions in nucleotide excision repair (NER); rad-23 functions in the global genome repair (GGR) pathway of NER and is necessary in germ cells to repair UV-induced DNA damage and for normal meiotic development following UV irradiation; rad-23 is partially necessary for efficient UV-induced apoptosis in germ cells; rad-23 is an ortholog of human hHR23A and hHR23B.

40090

6239