CELE_Y57A10C.6, Y57A10C.6

daf-22 encodes the C. elegans ortholog of human sterol carrier protein SCP2, which catalyzes the final step in peroxisomal fatty acid beta-oxidation; in C. elegans, DAF-22 activity is required for dauer pheromone biosynthesis; daf-22 mutant animals cannot produce dauer pheromone, but can synthesize weakly active longer-chain fatty acid derivatives; in synthesizing dauer pheromone, DAF-22 acts downstream of DHS-28, the C. elegans ortholog of human HSD17B4 (hydroxysteroid (17-beta) dehydrogenase 4); a DAF-22::GFP fusion protein is expressed in a punctate pattern in the intestine, hypodermis, and body wall muscle throughout the life cycle; DAF-22 expression in the intestine is sufficient to produce dauer pheromone.

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