CELE_Y48C3A.7, Y48C3A.7

mac-1 encodes a AAA ATPase (ATPase associated with a variety of cellular activities) most closely related to the ATPase subfamily that includes Drosophila Smallminded and the vertebrate NVL proteins; mac-1 activity is essential for proper regulation of fat storage and for normal larval development; MAC-1 interacts with the cell death regulator CED-4 in yeast two-hybrid assays and in tissue culture cells, and mac-1 overexpression in worms can prevent some programmed cell deaths; mac-1 mRNA is expressed throughout postembryonic development, with highest levels seen in hermaphrodites producing oocytes.

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