CELE_Y39G8C.1, Y39G8C.1

xrn-1 encodes a 5'-3' exoribonuclease that is orthologous to Saccharomyces cerevisiae Xrnp1, a key component of the yeast 5'-3' mRNA degradation pathway; in C. elegans, XRN-1 activity is required during embryogenesis for completion of ventral enclosure, the morphogenetic process whereby the ventral epithelial cells cover and seal the interior cells of the embryo; in addition, XRN-1 also plays a role in facilitating RNA interference (RNAi), likely acting in the same pathway as the DCR-1/Dicer ribonuclease; to date, XRN-1 expression has been reported in adult hypodermal and rectal cells.

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