CELE_F26H11.5, F26H11.5

exl-1 encodes a putative chloride intracellular channel (CLIC) paralogous to EXC-4; transgenic EXL-1 can partially rescue the exc-4(rh133) mutant phenotype when its expression is driven with an exc-4 promoter; EXL-1 is localized to lysosomes in intestinal cells and coelomocytes, endoplasmic reticulum in coelomocytes, Golgi apparatus in muscle and the neurons PVD and CAN, plasma membrane in muscle arms, and to dense bodies linking muscle cytoskeleton to hypodermis through muscle cell membranes; EXL-1 has an N-terminal PTM domain required for its membrane targeting, and a C-terminal domain resembling omega-type glutathione-S-transferases; EXL-1 has no known function in vivo, and exl-1(ok857) mutants have no obvious phenotype.

40381

6239