CELE_C13B4.2, C13B4.2

usp-14 encodes a homolog of ubiquitin-specific protease 14 (Usp14), a highly conserved thiol protease that hydrolyzes the peptide bond at the C-terminal glycine of ubiquitin (OMIM:607274, mutations are associated with synaptic defects in ataxia mice); by homology, USP-14 is predicted to function in ubiquitin-mediated protein degradation, or regulation of protein localization or activity; as loss of USP-14 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of USP-14 in C. elegans development and/or behavior is not yet known.

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