Caenorhabditis elegans

SBDS-1

CELE_W06E11.4, W06E11.4
W06E11.4 encodes an ortholog of human SBDS (OMIM:607444, mutated in Shwachman-Bodian-Diamond syndrome) and S. cerevisiae Sdo1p, that is required for the extended lifespan of daf-2(e1370) mutants; W06E11.4 is expressed ubiquitously (or nearly so) in somatic larval and adult tissues; by orthology with yeast Sdo1p, W06E11.4 is predicted to be a nucleolar protein required for maturation of 60S ribosomal subunits; W06E11.4 shares an operon with tag-266 and T19C3.7.
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