CELE_C14B1.4, swd-3.1, swd-3, tag-125, wdr-5, C14B1.4

wdr-5.1 encodes a WD40 repeat-containing protein that is the C. elegans ortholog of mammalian WDR5, a member of a conserved H3K4 trimethylation (H3K4me3) complex; WDR-5.1 functions to regulate H3K4 methylation levels and to negatively regulate adult worm lifespan; WDR-5.1 activity also antagonizes SynMuv transcriptional repressors; WDR-5.1 is broadly expressed beginning at the 20-cell stage of embryogenesis with continuing expression seen, albeit more restricted, through adulthood; WDR-5.1 localizes to the nucleus.

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