F52C9.7, CELE_F52C9.7

mog-3 encodes a conserved nuclear protein which shares homology to a yeast splicing factor: MOG-3 contains two motifs in its N-terminus that are fully conserved from yeasts to vertebrates; necessary for oogenesis and robust germ line proliferation; mog-3 and gld-3 functions synergistically to promote meiosis progression; MOG-3, MEP-1 and CIR-1 belong to single complex; MOG-3 interacts with N-terminus but not the conserved N-terminus motifs of MEP-1 and that is necessary and sufficient for nuclear zinc-finger MEP-1 protein binding; MOG-3 interacts with CIR-1 and with MEP-1 via two distinct domains; MOG proteins represses fem-3 via MEP-1 binding; mog-3 is expressed at steady state levels throughout embryogenesis and during larval development when hermaphrodites switch to oogenesis and also in adults; MOG-3 is a ubiquitous nuclear protein mainly expressed in oocyte lineage; similar to CIR-1, MOG-3 is also detected in somatic and meiotic nuclei as well as developing L4 vulva.

40961

6239