Caenorhabditis elegans
MET-2
CELE_R05D3.11, R05D3.11
met-2 encodes a histone methyltransferase similar to human SETDB1; during development, met-2 acts as a class B synMuv gene: loss of met-2 activity in the background of a class A or class C synMuv mutant, such as lin-15A or trr-1, respectively, results in a multivulval phenotype, indicating that met-2 acts to negatively regulate vulval cell fate specification; as met-2 is required for normal levels of histone H3K36 and H3K9 trimethylation and met-2;lin-15A animals show an increase in lin-3 EGF expression, met-2 likely acts as part of a transcriptional repressor complex that negatively regulates lin-3 EGF transcription to restrict vulval development to three of the six cells in the vulval equivalence group; in addition, genetic studies indicate that met-2 likely acts redundantly with met-1 to inhibit vulval cell fates.
GO Process (11)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- apoptotic process [IMP]
- gamete generation [IMP]
- hermaphrodite genitalia development [IMP]
- histone H3-K36 methylation [IMP]
- histone H3-K9 methylation [IMP]
- negative regulation of meiosis [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- negative regulation of vulval development [IGI, IMP]
- regulation of gene expression, epigenetic [IMP]
- reproduction [IMP]
- vulval cell fate commitment [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
41387
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- Interactors 5
- Interactions 10
- Network