CELE_ZK370.2, cem-1, ZK370.2

sma-2 encodes, along with sma-3 and sma-4, one of three C. elegans Smad proteins, with SMA-2 and SMA-3 most closely related to receptor-regulated Smads (R-Smads) and SMA-4 more closely related to co-mediator Smads (CoSmads); during development, SMA-2 functions in a TGF-beta signaling pathway to regulate body size and specification of sensory structures in the male tail; sma-2, through this pathway, also regulates reproductive aging; studies show that reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; a sma-2::gfp reporter is expressed in the pharynx, intestine, and hypodermis.

41432

6239