Caenorhabditis elegans
EIF-3.D
CELE_R08D7.3, R08D7.3
eif-3.D encodes the C. elegans ortholog of the translation initiation factor 3 subunit d (eIF3d/Moe1); by homology, EIF-3.D is predicted to function as part of the eIF3 translation initiation complex but also as part of a Ras-mediated pathway that regulates mitotic spindle formation; in C. elegans, large-scale RNAi screens indicate that eif-3.D is required for embryonic and germline development, locomotion, and normal rates of post-embryonic growth; in the early embryo, eif-3.D is specifically required for the fidelity of meiotic divisions and normal pseudocleavage; eif-3.D function is likely conserved, as expression of eif-3.D in Schizosaccharomyces pombe can rescue the mitotic spindle and growth defects associated with moe1 mutant cells; to date, eif-3.D expression has been reported in anterior neurons and the pharynx, beginning at late stages of embryogenesis.
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
41467
6239
Switch View:
- Interactors 32
- Interactions 34
- Network