CELE_F54C8.5, F54C8.5

rheb-1 encodes a GTPase orthologous to the mammalian Rheb and Rheb1 GTPases; by homology, RHEB-1 is predicted to function as a regulator of LET_363/TOR function; in C. elegans, rheb-1 plays an essential role in mediating intermittent fasting (IF)-induced longevity; further, loss of rheb-1 activity via RNAi indicates that rheb-1 is involved in the mitochondrial unfolded protein response and that its function is required for normal growth rates, body size, osmoregulation, reproduction, and locomotion.

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